Resident Evil: The Final Chapter is a 2016 science fiction action horror film written and directed by Paul W. S. Anderson. It is the sequel to Resident Evil: Retribution (2012) and the sixth and final installment in the Resident Evil film series, which is loosely based on the Capcom survival horror video game series Resident Evil. The film stars Milla Jovovich, Ali Larter, Shawn Roberts, Ruby Rose, Eoin Macken, William Levy, and Iain Glen. In the film, Alice and her friends are betrayed by Albert Wesker, who gathers the entire forces of Umbrella into one final strike against the apocalypse survivors.
Dr. James Marcus, the original founder of the Umbrella Corporation, had a daughter who was dying of premature aging. Desperate to save her, Marcus developed the T-virus as a way to cure all diseases on Earth. After having had his creation taken away from him, Marcus’ business partner Dr. Alexander Isaacs (Iain Glen) tried to convince Marcus to use the T-virus for military purposes. When he refused, Isaacs ordered Albert Wesker (Shawn Roberts) to kill Marcus.
Some time after the events of the previous film, Alice (Milla Jovovich) awakens in the now-ruined White House, after being betrayed once again by Wesker. While searching for survivors, the Red Queen (Ever Gabo Anderson) appears and tells Alice that she must return to the Hive in Raccoon City within 48 hours, where the Umbrella Corporation has developed an airborne antivirus, which will kill every organism infected by the T-virus, before the remainder of humankind is wiped out. When asked why she’s betraying her creators, the Red Queen simply says that she will tell Alice once she arrives at The Hive.
On her way to Raccoon City, Alice is captured by Isaacs, whose clone Alice previously killed, but she manages to escape his convoy. Alice later arrives in the now-destroyed Raccoon City and is captured by a group of survivors, consisting of Doc (Eoin Macken), Abigail (Ruby Rose), Christian (William Levy), Cobalt (Rola), Razor (Fraser James), and Claire Redfield (Ali Larter), who is revealed to be alive after the attack on Arcadia. After learning that a group of armored vehicles and a horde of zombies is coming their way, the group prepares to make their last stand. They manage to defeat the enemy forces, although Cobalt is killed in the process. The group later realizes that a second horde is coming in their direction.
With no defenses left, Alice and the crew decide to get to the Hive entrance, located at the bottom of the atomic bomb crater which destroyed the city. However, Wesker, having taken control of the Hive, releases mutated guard dogs, killing Christian. Upon arriving at the Hive, the Red Queen appears again to Alice and explains the reason of her betrayal. She revealed that a video was uploaded to her program which contained the recording of the Umbrella executives, including Isaacs, having a meeting regarding the world, formulating a plan to release the T-virus on purpose in order to cleanse the world, save the rich and powerful with cryogenic capsules hidden in the Hive, and later rebuild the world in their image. The Red Queen, although programmed to never hurt an Umbrella employee, was also programmed to value human life, which is why she enlists Alice’s help in order to stop Isaacs. The Red Queen also warns Alice about one of the group being a spy for Umbrella.
Entering the Hive, the group encounter several traps, and Abigail and Razor are killed. After planting bombs around the Hive, Alice confronts the real Isaacs, while she and Claire are captured by Wesker and Doc, Umbrella’s spy. A cryogenic capsule opens, revealing Alicia Marcus, Umbrella’s co-leader and Marcus’s daughter; Alice is revealed to be just a clone of Alicia. Isaacs plans to eliminate Alicia and gain full control of Umbrella, but Alicia “fires” Wesker, which signals the Red Queen to crush his legs with a security door. Doc tries to shoot Alice, but his gun is empty – as Alice had deduced his treachery earlier – and he is shot dead by Claire.
Encouraged by Alicia’s words, Alice and Claire fight Isaacs, who is eventually killed by his own clone – the one Alice had encountered en route to the city – and Alice manages to release the antivirus, killing the undead. The bombs planted within the Hive explode, killing everyone inside, including Alicia, all the frozen Umbrella employees, and Wesker. Claire later wakes Alice, who survived as the antivirus killed the T-virus within Alice’s body. The Red Queen gives Alice an upload of all Alicia’s memories of childhood. Some time later, Alice travels to Manhattan, stating that the antivirus could take several years to reach all corners of the globe and until then, her mission isn’t over, as several large creatures pursue her.